ABEmax mRNA encodes the ABEmax (Adenine Base Editor) protein, a second-generation genome-editing tool for precise adenine-to-guanine (A-to-G) conversions in DNA. Delivered as mRNA, it ensures rapid, high transient expression proportional to mRNA quantity without requiring nuclear uptake. Extensively characterized for its targeting window and off-target effects, ABEmax is ideal for research in gene function, genetic diseases, and therapeutic development.
Croyez’s ABEmax mRNA is produced through in vitro transcription, featuring a Cap1-modified 5' end, a poly(A) tail at the 3' end, and modified nucleotides to reduce immune response. These enhancements ensure stability and performance, allowing the mRNA to function like natural mature mRNAs in cells.